Lord Vaizey worked as Culture Minister between 2010 and 2016, and most recently was the Member of Parliament for Didcot and Wantage from 2015 to 2019. He was appointed peer to the House of Lords by Boris Johnson in August 2020.

In November 2019 he announced he would not stand for re-election to focus on his passion for the arts and creative industries.

He is a big advocate of the video games industry in Britain, having secured tax breaks for game development studios, and has been recognised by GamesIndustry.Biz as one of the 100 most influential people in the British games industry.